Marvel Mystic Mayhem Tier List & Reroll Guide (June 2025)
Updated on June 26, 2025: Adjusted the tier list and Reroll guide for post release. There's a lot of heroes in Marvel Mystic Mayhem and you have a limited team size so let's analyze each hero to look for the best ones. I'll also provide tips for each hero as well as best Artifacts, Highlights, and synergies. We'll finish off with a Reroll guide since starting out with a strong hero helps a ton early. Here's my Marvel Mystic Mayhem tier list and Reroll guide. Table of contents Marvel Mystic Mayhem Hero Tier List S-Tier Heroes A-Tier Heroes B-Tier Heroes C-Tier Heroes Marvel Mystic Mayhem Reroll Guide Marvel Mystic Mayhem Hero Tier List Reasons Below - Image by Destructoid The best heroes in Marvel Mystic Mayhem are usually those that excel in their own class category and specialize in a certain area. For Defenders you want great tankiness and taunts, for Strikers and Fighters you want great damage and mobility, and for Controllers you want either great healing or excellent utility and crowdcontrol. I'll analyze each hero below but ranking reasons and tips. Legendary Artifacts are always a must but below I'll list the best Epic Artifacts since they're easier to get. The tier breakdowns are as follows: S-Tier: Universally the best options for each Class with the best damage, tanking, healing, and utility. A-Tier: The best alternative to S-Tier heroes that still pack a lot of power. B-Tier: Heroes that either shine in a specific build or struggle to fit in a wider variety of teams. C-Tier: Heroes that are inflexibile and good in specific scenarios but overall underpowered. Let's dive into ranking reasons and tips for each hero below. S-Tier Heroes Hero Ranking Reason Tips JuggernautDefenderMystic ArtsLegendary • Incredible tanking ability with % damage reduction and shields• Juggernaut is in S-Tier with a caveat that you have to level him until you get the Bad Attitude Taunt• Once you have Taunt on Juggernaut he's probably the best Defender in Marvel Mystic Mayhem• You just have to heal him and watch him tank everything • Best Artifacts: Force Field GloveSling RingAvengers ID CardUndriarn• Best Highlights:Blessing of VishantiMonster WithinStand StrongNever Surrender Doctor StrangeControllerMystic ArtsLegendary • The most flexible and adaptable controller with Vishanti's Blessing for heals, buff, and debuffs on demand• Ultimate is one of the best if no the best heals in the game• Fits into any team composition • Best Artifacts: Gamma MutagenForce Field GloveAvengers ID CardUndriarn• Best Highlights:Vow to ProtectAncient FrontierTime for Walkies!Adapt and Evolve ThorFighterEnergyLegendary • Best damage and mobility combination in the game so he's extremely versatile• Thor's Ultimate has some of the best AOE burst damage among Fighters• Best Fighter in the game • Best Artifacts: S.H.I.E.L.D Flight PackThe Hand's ShurikenUnstable Molecules• Best Highlights:The Worthy OnesAmbitionRising from AshesBy Cyttorak's Command Iron ManStrikerEnergyLegendary • One of the best Strikers in the game for AOE damage• Has incredible mobility like Thor to target key targets in a fight or reposition• Ignores enemy defense• Requires defensive items because he's really squishy • Best Artifacts: The Hand's ShurikenMidnight GunUnstable Molecules• Best Highlights:Fight as OneGreat MindsRaise Like the PheonixMake a Dream Scarlet WitchStrikerMystic ArtsLegendary • Best Striker in the game for clearing enemies because Chaos Blade resets on kills• Her Ultimate is a pure boss killer, especially with crits• Stack Crit artifacts and highlights and she'll carry you • Best Artifacts: The Hand's ShurikenMidnight GunUnstable Molecules• Best Highlights:Fight as OneGreat MindsRaise Like the PheonixMake a Dream Emma FrostControllerMutationLegendary • Very versatile Controller because she's both a healer and off-DPS• Excellent debuff with Queen's Command which makes enemies attack each other• Headmistress passive is so powerful on Strikers and Diamond Shield buffs Tanks incredibly well • Best Artifacts: Avengers ID CardGamma MutagenUnstable Molecules• Best Highlights:Ancient FrontierNo Strings on MeGuardian of RealityWeavers of Dream ArmorDefenderMutationEpic • Armor is on the verge of A-Tier but I kept her in S on release due to her amazing mix of damage, tanking, and taunting• Armor is an off-DPS tank but you need to max out defensive stats on her artifacts and highlights• Enhanced Armor can stun for 5 seconds with Heart 1 from Armor Soul Saga which is incredible crowd-control• Her Ancestral Armor taunts enemies so that you can tank more easily • Best Artifacts: Asgard ShieldGamma MutagenUndriarnAvengers ID Card• Best Highlights:Blessing of VishantiLearn from the BestMonster WithinLight in Darkness A-Tier Heroes Hero Ranking Reason Tips HulkDefenderEnergyEpic • Hulk has incredible defenses, reduces enemy damage, and deals okay damage but he has not Taunt so he's A-Tier• You can
Updated on June 26, 2025: Adjusted the tier list and Reroll guide for post release.
There's a lot of heroes in Marvel Mystic Mayhem and you have a limited team size so let's analyze each hero to look for the best ones. I'll also provide tips for each hero as well as best Artifacts, Highlights, and synergies. We'll finish off with a Reroll guide since starting out with a strong hero helps a ton early. Here's my Marvel Mystic Mayhem tier list and Reroll guide.
Table of contents
Marvel Mystic Mayhem Hero Tier List
The best heroes in Marvel Mystic Mayhem are usually those that excel in their own class category and specialize in a certain area. For Defenders you want great tankiness and taunts, for Strikers and Fighters you want great damage and mobility, and for Controllers you want either great healing or excellent utility and crowdcontrol. I'll analyze each hero below but ranking reasons and tips. Legendary Artifacts are always a must but below I'll list the best Epic Artifacts since they're easier to get. The tier breakdowns are as follows:
- S-Tier: Universally the best options for each Class with the best damage, tanking, healing, and utility.
- A-Tier: The best alternative to S-Tier heroes that still pack a lot of power.
- B-Tier: Heroes that either shine in a specific build or struggle to fit in a wider variety of teams.
- C-Tier: Heroes that are inflexibile and good in specific scenarios but overall underpowered.
Let's dive into ranking reasons and tips for each hero below.
S-Tier Heroes
| Hero | Ranking Reason | Tips |
|---|---|---|
 Juggernaut Defender Mystic Arts Legendary | • Incredible tanking ability with % damage reduction and shields • Juggernaut is in S-Tier with a caveat that you have to level him until you get the Bad Attitude Taunt • Once you have Taunt on Juggernaut he's probably the best Defender in Marvel Mystic Mayhem • You just have to heal him and watch him tank everything | • Best Artifacts: Force Field Glove Sling Ring Avengers ID Card Undriarn • Best Highlights: Blessing of Vishanti Monster Within Stand Strong Never Surrender |
 Doctor Strange Controller Mystic Arts Legendary | • The most flexible and adaptable controller with Vishanti's Blessing for heals, buff, and debuffs on demand • Ultimate is one of the best if no the best heals in the game • Fits into any team composition | • Best Artifacts: Gamma Mutagen Force Field Glove Avengers ID Card Undriarn • Best Highlights: Vow to Protect Ancient Frontier Time for Walkies! Adapt and Evolve |
 Thor Fighter Energy Legendary | • Best damage and mobility combination in the game so he's extremely versatile • Thor's Ultimate has some of the best AOE burst damage among Fighters • Best Fighter in the game | • Best Artifacts: S.H.I.E.L.D Flight Pack The Hand's Shuriken Unstable Molecules • Best Highlights: The Worthy Ones Ambition Rising from Ashes By Cyttorak's Command |
 Iron Man Striker Energy Legendary | • One of the best Strikers in the game for AOE damage • Has incredible mobility like Thor to target key targets in a fight or reposition • Ignores enemy defense • Requires defensive items because he's really squishy | • Best Artifacts: The Hand's Shuriken Midnight Gun Unstable Molecules • Best Highlights: Fight as One Great Minds Raise Like the Pheonix Make a Dream |
 Scarlet Witch Striker Mystic Arts Legendary | • Best Striker in the game for clearing enemies because Chaos Blade resets on kills • Her Ultimate is a pure boss killer, especially with crits • Stack Crit artifacts and highlights and she'll carry you | • Best Artifacts: The Hand's Shuriken Midnight Gun Unstable Molecules • Best Highlights: Fight as One Great Minds Raise Like the Pheonix Make a Dream |
 Emma Frost Controller Mutation Legendary | • Very versatile Controller because she's both a healer and off-DPS • Excellent debuff with Queen's Command which makes enemies attack each other • Headmistress passive is so powerful on Strikers and Diamond Shield buffs Tanks incredibly well | • Best Artifacts: Avengers ID Card Gamma Mutagen Unstable Molecules • Best Highlights: Ancient Frontier No Strings on Me Guardian of Reality Weavers of Dream |
 Armor Defender Mutation Epic | • Armor is on the verge of A-Tier but I kept her in S on release due to her amazing mix of damage, tanking, and taunting • Armor is an off-DPS tank but you need to max out defensive stats on her artifacts and highlights • Enhanced Armor can stun for 5 seconds with Heart 1 from Armor Soul Saga which is incredible crowd-control • Her Ancestral Armor taunts enemies so that you can tank more easily | • Best Artifacts: Asgard Shield Gamma Mutagen Undriarn Avengers ID Card • Best Highlights: Blessing of Vishanti Learn from the Best Monster Within Light in Darkness |
A-Tier Heroes
| Hero | Ranking Reason | Tips |
|---|---|---|
 Hulk Defender Energy Epic | • Hulk has incredible defenses, reduces enemy damage, and deals okay damage but he has not Taunt so he's A-Tier • You can still do great things with Hulk since he has incredible sustain with Gamma Quake and buffs • Has excellent mobility to reposition where he's needed | • Best Artifacts: Force Field Glove Sling Ring Avengers ID Card Undriarn • Best Highlights: Blessing of Vishanti Monster Within Stand Strong Light in Darkness |
 Lady Bullseye Striker Weaponry Epic | • An easy to get Striker with tons of chaining damage skills with low cooldowns and Mana costs • Works best with Psylocke to chain DPS but can also work solo • Max out crit with artifacts and highlights and focus on assassinating key targets in combat | • Best Artifacts: The Hand's Shuriken Unstable Molecules Midnight Gun • Best Highlights: Fight as One A Hired Blade Raise Like the Pheonix Make a Dream |
 Psylocke Fighter Mutation Epic | • One of the two best Fighters in the game along with Thor • Excellent mix of high single and AOE damage with mobility • Butterfly Shadow from Mind Hunter passive and Telekinetic Blade skill is excellent for finishing off key enemies before they're healed • Crit is a must on artifacts and highlights | • Best Artifacts: The Hand's Shuriken Unstable Molecules Midnight Gun • Best Highlights: The Worthy Ones Rising from Ashes War Paint By Cyttorak's Command |
 Sentry Defender Cosmic Epic | • Great alternative for a tank because Sentry also has Taunt with Exploding Suns • Sentry trades utility for off-DPS damage which he can enhance once you stack up Million Suns • Million Suns stacks are flexible for defense with Celestial Drop or utility to taunt more enemies with Exploding Suns | • Best Artifacts: Force Field Glove Sling Ring Avengers ID Card Undriarn • Best Highlights: Blessing of Vishanti Monster Within Stand Strong Never Surrender |
 Sleepwalker Controller Energy Epic | • Sleepwalker has worse healing than Doctor Strange but better damage so he can be a good off-DPS • His Ultimate damages all enemies on the battlefield which is amazing if you can finish off enemies before they're healed • Best combined with powerful burst damage Strikers or Fighters due to Dream Power's buff | • Best Artifacts: Force Field Glove Avengers ID Card Undriarn Gamma Mutagen • Best Highlights: Vow to Protect Ancient Frontier Guardian of Reality Adapt and Evolve |
 Misty Knight Striker Weaponry Epic | • People hate on Misty Knight due to her lack of mobility but her damage is still excellent • You just have to position well to make the most of her ultimate and her marked target damage • She's a great target for Sleepwalker's Dream Power due to her ult | • Best Artifacts: The Hand's Shuriken Unstable Molecules Midnight Gun • Best Highlights: Fight as One Raise Like the Pheonix Great Minds Make a Dream |
B-Tier Heroes
| Hero | Ranking Reason | Tips |
|---|---|---|
 Moon Knight Fighter Concussive Epic | • Moon Knight struggles as a jack-of-all-trades master-of-none with both Fighter and Controller abilities • Still he can be useful to complement a team and be flexible • Pairing him in a team with Thor or Doppleganger to stack incredible attack speed can be fun | • Best Artifacts: Avengers ID Card Gamma Mutagen The Hand's Shuriken • Best Highlights: The Worthy Ones Touched by Khonshu Rising from Ashes By Cyttorak's Command |
 Spider-Man Controller Concussive Legendary | • It's kind of risky running Spider-Man in the controller slot because he lacks healing • Instead, he focuses on crowd-control, powerful debuffs, and great AOE damage • If you can make up for his lack of heals as a controller he becomes incredibly useful • The best non-heal Controller due to amazing utility | • Best Artifacts: The Hand's Shuriken Unstable Molecules Midnight Gun • Best Highlights: Fight as One Raise Like the Pheonix Great Minds Make a Dream |
 Angela Defender Weaponry Epic | • Angela has no Taunt so I ranked a bit lower for Defender standards but she does great damage for a Defender • Along with her good off-DPS she has great defenses and her passive is better the longer she fights • You want to position Angela with her high mobility so that she has no allies nearby for Lone Fighter passive to trigger | • Best Artifacts: Asgard Shield Gamma Mutagen Avengers ID Card Undriarn • Best Highlights: Blessing of Vishanti Learn from the Best Monster Within Light in Darkness |
 Black Knight Fighter Mystic Arts Epic | • Black Knight is incredibly strong with Moon Knight or Doppleganger to boost his attack speed • Otherwise his high basic attack damage remains unused to its fullest potential • He's quite durable for a Fighter due to the revive but he still needs heals and support • Stack attack speed for artifacts and highlights | • Best Artifacts: S.H.I.E.L.D Flight Pack The Hand's Shuriken Unstable Molecules Stormbreaker • Best Highlights: The Worthy Ones Ambition Rising from Ashes Hear Me Roar |
 Moon Girl Controller Weaponry Legendary | • Moon Girl relies too heavily on being a good DPS without much utility nor healing as a Controller • She can be great in certain team comps but overall if you want a no-heal Controller pick Spider-Man • That said, for a Controller she and the dino have great off-DPS | • Best Artifacts: Avengers ID Card Gamma Mutagen Unstable Molecules • Best Highlights: Ancient Frontier No Strings on Me Guardian of Reality Weavers of Dream |
 Doppleganger Fighter Cosmic Epic | • Good mobility and basic attack focused damage • Becomes really good with full attack speed Artifacts and Highlights and the last Spider-Siphon passive to spam Ult • Paired well with Black Knight and/or Moon Knight • Otherwise, he's not the best Fighter pick due to low damage | • Best Artifacts: S.H.I.E.L.D Flight Pack The Hand's Shuriken Unstable Molecules • Best Highlights: The Worthy Ones Ambition Rising from Ashes By Cyttorak's Command |
 Echo Fighter Weaponry Epic | • Echo is best paired with high damage heroes like Lady Bullseye and Psylocke due to her passive and Ronin's Shadow • She desperately needs a Defender to fight alongside her since she's squishy • Very dependent on her team composition | • Best Artifacts: The Hand's Shuriken Midnight Gun Avengers ID Card Gamma Mutagen • Best Highlights: War Paint Ambition The Worthy Ones By Cyttorak's Command |
 Storm Striker Mutation Legendary | • She's lower than other Legendaries due to her lower overall DPS • Storm's usefulness comes from stacking debuffs on enemies, benefitting from her later passives and activating debuff effects with her abilities • She goes well with other Heroes who can apply AOE debuffs to further increase Storm's utility and damage from her passives | • Best Artifacts: The Hand's Shuriken Unstable Molecules Midnight Gun S.H.I.E.L.D Flight Pack • Best Highlights: Fight as One Friends on Street Raise Like the Pheonix Make a Dream |
C-Tier Heroes
| Hero | Ranking Reason | Tips |
|---|---|---|
 Falcon Controller Concussive EpicEpic | • Falcon is all about Exposed Weakness to increase enemy Physical damage taken • Other than that his Mobility is great but he falls short in other aspects • His ultimate puts him in melee range but he's generally squishy • A weird mix of DPS, mobility and debuffs that don't really complement each other | • Best Artifacts: Avengers ID Card The Hand's Shuriken Unstable Molecules • Best Highlights: Ancient Frontier No Strings on Me Guardian of Reality Weavers of Dream |
 Thread Striker Mystic Arts Epic | • Thread is excellent in a summon based team comp with Moon Girl • Otherwise his DPS is lackluster so he's a very specific hero • That said, the Threadlings can help tank some damage so there's a bit of utility to Thread as well | • Best Artifacts: Gamma Mutagen Avengers ID Card Unstable Molecules Undriarn • Best Highlights: Fight as One Friends on Street A Hired Blade Ancient Allies |
 Dreamqueen Controller Mystic Arts Epic | • Dreamqueen does great damage and has a good team skill dmg buff but it really hurts that she lacks any strong CC or healing • You can make an excellent DPS comp with her but you'll struggle on harder modes without healing if she's your only Controller | • Best Artifacts: Avengers ID Card Gamma Mutagen Unstable Molecules • Best Highlights: Ancient Frontier No Strings on Me Guardian of Reality Weavers of Dream |
 Mister Negative Fighter Mystic Arts Epic | • Very inflexibile hero that requires a specific comp with debuff heroes since his damage scales with debuffs • Works best with Storm and/or Spiderman • Can deal incredible burst damage with stacked debuffs • Otherwise he's not the best | • Best Artifacts: Gamma Mutagen The Hand's Shuriken Unstable Molecules • Best Highlights: The Worthy Ones Touched by Khonshu Rising from Ashes Hear Me Roar |
 Man-Thing Controller Mutation Epic | • Similar to Thread Man-Thing is quite a specific Hero that shines in a summon team comp • Extremely strong with Thread and Moon Girl • Otherwise mediocre | • Best Artifacts: Force Field Glove Avengers ID Card Undriarn • Best Highlights: Ancient Frontier Guardian of Reality Vow to Protect Adapt and Evolve |
Marvel Mystic Mayhem Reroll Guide
There are three things you need to know about Marvel Mystic Mayhem's Reroll system including how to reroll (Step 3):
- Gacha Unlocks at Level 10: Getting to Level 10 unlocks the Gacha Banners and supplies you with the needed materials to call. You can do this via Story missions and Daily missions which takes around 15 to 20 minutes. Make sure to disable ultimate animations if you're rerolling because this drastically speeds up the game. You can do this by going to the Three Vertical Lines Top Right > Settings > Battle Tab > Do Not Play Ultimate Move Full Animation.
- Banners to Spin On & Which Heroes to Get: You'll be stocked with a decent amount of resources to call via Team Level, Daily Missions, Story, and Codes (Found Below). Then, I recommend skipping the Iron Man Forge the Future banner and rolling on the other banner since this is where you'll have more Shadow Keys for more calls. Look for Heroes like Juggernaut for tanking, Doctor Strange for Controllers, Thor for Fighters, and Scarlet Witch to Strikers. Path to Legends can aslo get you a guaranteed S-Tier character after 40 calls. It really helps to get one of these heroes to start and it's worth Rerolling your account for them (See below).
- How to Reroll (Image Above): If you're not happy with what you got you can reroll your account and repeat the 15 to 20 minute grind to get to Level 10 again. Here's how:
- Tap the three vertical lines in the top right.
- Go to Settings.
- Tap User in the lower left.
- Go to the last tab on the left.
- Tap Continue on Start a new game.
That's it for my Marvel Mystic Mayhem tier list and reroll guide. Don't forget to claim our Marvel Mystic Mayhem codes for free goodies.
The post Marvel Mystic Mayhem Tier List & Reroll Guide (June 2025) appeared first on Destructoid.
